Distinct place cell dynamics in CA1 and CA3 encode experience in new environments

Abstract When exploring new environments animals form spatial memories that are updated with experience and retrieved upon re-exposure to the same environment. The hippocampus is thought support these memory processes, but how this achieved by different subnetworks such as CA1 CA3 remains unclear. To understand hippocampal representations emerge evolve during familiarization, we performed 2-photon calcium imaging in mice running virtual compared trial-to-trial dynamics of place cells over days. We find fields rapidly tend shift backwards from remap environment a day later. In contrast, gradually show more stable day-to-day dynamics. These results reflect roles processing familiarization constrain potential mechanisms them.